GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4691139 | 1 | rs6536883 | chr4:165900704 | C4orf39 | chr4:165878100-165880273:+ | 0.2 | 5.54 | 5.14E-8 | Ovarian cancer in BRCA1 mutation carriers |
| THCA | cis | rs11734488 | 1 | rs6537243 | chr4:139129215 | SLC7A11 | chr4:139085248-139163503:- | 0.23 | 4.55 | 6.95E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs10862219 | 1 | rs6539545 | chr12:81433197 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.7 | 3.37E-6 | Neuroticism |
| THCA | cis | rs12134133 | 1 | rs6540893 | chr1:207435727 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.52 | 2.67E-13 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs891378 | 1 | rs6540896 | chr1:207440851 | CD55 | chr1:207494817-207534309:+ | 0.15 | 6.72 | 5.14E-11 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs9308731 | 1 | rs6542334 | chr2:111907214 | BCL2L11 | chr2:111878491-111926022:+ | -0.14 | -3.4 | 0.000732 | Chronic lymphocytic leukemia |
| THCA | cis | rs1374313 | 1 | rs6542527 | chr2:120148080 | DBI | chr2:120124504-120130120:+ | -0.24 | -6.77 | 3.71E-11 | Obesity-related traits |
| THCA | cis | rs2041840 | 1 | rs6544065 | chr2:37497417 | CEBPZ | chr2:37428778-37458740:- | -0.18 | -3.92 | 0.000102 | Chronic lymphocytic leukemia |
| THCA | cis | rs6545883 | 1 | rs6545883 | chr2:61772257 | AHSA2 | chr2:61404553-61414058:+ | -0.23 | -9.58 | 5.49E-20 | Tuberculosis |
| THCA | cis | rs6545883 | 1 | rs6545883 | chr2:61772257 | C2orf74 | chr2:61372243-61391964:+ | 0.54 | 11.82 | 1.93E-28 | Tuberculosis |
| THCA | cis | rs962856 | 1 | rs6546294 | chr2:67562230 | ETAA1 | chr2:67624442-67637533:+ | -0.18 | -4.24 | 2.74E-5 | Pancreatic cancer |
| THCA | cis | rs10205487 | 1 | rs6546553 | chr2:70111711 | ASPRV1 | chr2:70187226-70314147:- | -0.13 | -3.5 | 0.000516 | Carotid plaque burden (smoking interaction) |
| THCA | cis | rs4665809 | 1 | rs6546726 | chr2:26275116 | GPR113 | chr2:26531041-26569685:- | -0.43 | -6.89 | 1.76E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546727 | chr2:26275282 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.78 | 3.54E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546728 | chr2:26276531 | GPR113 | chr2:26531041-26569685:- | -0.47 | -7.31 | 1.15E-12 | Gut microbiome composition (summer) |